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Monitoring parameters: - Urine pH (every 68 hours or per protocol) - Serum creatinine - Methotrexate plasma levels - Electrolytes (watch for metabolic alkalosis, hypokalemia) If urine pH is suboptimal: - Increase sodium bicarbonate infusion - Consider IV bolus doses - Add acetazolamide in selected cases Relation to rescue therapy: Urinary alkalinization does not replace Leucovorin rescue, but it is essential to prevent toxicity and ensure proper drug elimination

That's why people often notice results during the drip itself, not just hours later. How Long Does IV Hydration Last

It plays a crucial role in energy metabolism

Gewandter JS, Culakova E, Davis JN, Gada U, Guido JJ, Bearden JD,

This minimally invasive procedure is also performed under local anesthesia and offers a rapid return to normal activities