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Its role in preserving NAD+ and supporting mitochondrial health led to its use in advanced clinical longevity protocols as a tool to help protect NAD+

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HO-1 Antioxidant and Cytoprotective Pathway BPC-157 activates haem oxygenase-1 (HO-1), a key intracellular antioxidant and cytoprotective enzyme, which modulates oxidative stress, reduces lipid peroxidation, and protects cells from HNE (4-hydroxynonenal)-mediated growth inhibition

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In ambiguous cases, methylmalonic acid or homocysteine can help