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They also enabled the delivery of poorly soluble compounds with low bioavailability and rapid clearance 28

Studies using a stabilized radiolabeled (Ser8)GLP-1 revealed rapid uptake into the brain after intravenous (i.v.) administration without self-inhibition when challenged with increased doses of unlabeled (Ser8)GLP-1 or upon inhibition of brain GLP-1 influx upon pretreatment with exendin (939)