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Addressing blood-brain barrier impairment in Alzheimers disease

Similar findings have been observed in mice

Melatonin also affects key transcriptional pathways: SIRT1/forkhead box protein O (FOXO), Nrf2/ARE, the canonical Wnt pathway (Wnt/-catenin), and MAPK/ERK

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Ten minutes of forebrain ischemia in adult rats led to a significantly decreased number of intact neurons in hippocampal tissue, decreased concentrations of glutathione and ATP, and increased total nitrate/nitrite and thiobarbituric acid-reactive substances which accumulate in conditions of oxidative stress [133]