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Whether retatrutide, with its additional glucagon receptor agonism and potentially greater central nervous system penetration, shares or amplifies these neuroprotective effects is an open and genuinely important scientific question

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Authors' contributions MH drafted the manuscript

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This analysis confirmed the presence of Prlh/Calcr/Glp1r co-expressing neurons in the NTS of all three species, as well as Prlh -expressing cells with neither receptor present