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Ongoing studies continue to examine extracellular matrix remodeling, angiogenic signaling, immune regulation, epithelial barrier function, cell migration, and tissue homeostasis

describe compelling preclinical synergy of APR-246 in combination with azacitidine in TP53 mutated MDS and AML and, more importantly, identify a novel molecular mechanism underlying the observed synergy

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Here, a within-subjects comparison was performed using a two-way repeated measures ANOVA to assess mean differences in index scores between pre- and post-treatment conditions in the same animals

Both cationic bovine serum albumin (CBSA)-induced MN rats and idiopathic membranous nephropathy (IMN) patients exhibit a decreased relative abundance of L