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Jastreboff et al., 2022) documented superior weight loss and glycemic control compared to single-target GLP-1 agonists, with up to 22.5% body weight reduction at 72 weeks in the SURMOUNT-1 trial

Mechanistic evaluations in laboratory contexts may include peptidemetal binding interaction analysis, intracellular signaling pathway observation, gene expression pattern assessment, and downstream regulatory pathway mapping within experimental cellular systems designed for controlled scientific investigation