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A dynamics-based approach to drug design would represent a departure from traditional approaches, which focus on promoting a specific conformation rather than retaining or enhancing particular modes of conformational mobility that might contribute to efficacy by mechanisms other than high-affinity binding

doi: 10.1186/s13293-016-0059-9 10 WangWVolkowNDBergerNADavisPBKaelberDCXuR