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Then, NF-B signaling was activated and NF-B-p65 nuclear translocation was enhanced, ultimately enhancing the expression of NLRP3, IL-1, and IL-18

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The biotransformation that leads to the delayed formation of thiomethyl metabolites via the thiomethyl shunt pathway has been shown to occur in rodents via the enterohepatic circulation and biliary excretion of the glutathione-derived conjugates into the intestine ( 9 )

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