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Homocysteine leads to the degradation of intestinal epithelial TJs by inhibiting the expression of thrombomodulin and the binding of tissue plasminogen activator to endothelial cells, as well as stimulating the expression of oxidative and inflammatory factors, further contributing to endothelial dysfunction in CKD (31)

Matter 1 (2), 345368

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Common methods included decoctions (boiling roots or bark to extract water-soluble compounds), infusions (steeping leaves or flowers), ointments and pastes (mixing crushed herbs with oils or ghee), medicated oils (herbal infusions in carrier oils like Azadirachta indica or sesame), powders, and fermented preparations like Arishta or Asava for oral detoxification