1 hour before lipopolysaccharide, then every 4 hours thereafter) increases hepatic and mitochondrial glutathione levels, reduces lipopolysaccharide-induced liver enzyme elevation, reactive oxygen intermediate production, and mitochondrial dysfunction, and maintains near 100% survival in endotoxemic mice [5]
Furthermore, like most transcription factors, direct targeting of NRF2 itself has been extremely challenging
For instance, our Liposomal Vitamin C can provide an extra layer of support from within
Areas of research interest Technical specifications Compound Information Copper-binding tripeptide complex Storage & Stability Lyophilized (powder) -20C long-term stable in sealed lyophilized form Reconstituted 2-8C use within 30 days of reconstitution Light Protect from light during storage and reconstitution Room temperature Short-term tolerant during shipping
Elevated intracellular GSH levels represent both a barrier to conventional therapies and an opportunity to design redox-responsive drug delivery systems