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Research suggests that metformin can reduce vitamin B12 absorption in the digestive tract, potentially leading to lower B12 levels over time

Muscles can be trained more safely at higher intensities due to enhanced joint and tissue stability

The glycine residues provide flexibility at key points

We need to watch these patients closely to make sure they get enough B12

Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing