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During energy deprivation, astrocytes metabolize fatty acids by -oxidation to produce ketone bodies and transfer ketone bodies via APOE lipid carriers to neurons that in turn use the ketones to produce ATP in mitochondria [59]

In addition, in several studies, NAD depletion enhanced cancer cell susceptibility to oxidative stress through a reduction in antioxidative capacity by downregulating antioxidant proteins

Decreased renal gluconeogenesis is a hallmark of chronic kidney disease

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