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Summary of CV and Renal Outcomes with SGLT2i and DPP4i Agents SGLT2: Inhibitor Cardiovascular Outcome Trials Cardiovascular outcome trials (CVOTs) have consistently shown that treatment with SGLT2i reduces hospitalization for heart failure (HHF) and secondary renal outcomes in terms of incident or worsening nephropathy in patients with T2DM and CV disease

In the Fear Conditioning Memory Test, the HFD SEMA group showed a significantly better learning response than the untreated HFD group, characterized by a longer hesitation time before stepping onto the electrified grid

Glutaminase (GLS/GLS2) catalyzes it and transforms it to glutamate

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