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The bioactivity of scExe4 was evaluated through measuring GSIS using pancreatic iGL cells, which release Gaussia luciferase-fused insulin in response to high glucose levels 21

In AD, altered A 2A and A 1 receptor-mediated signaling modulates EAAT2 expression, AQP4 polarization, and inflammatory states, while P2X 7 receptor hyperactivation exacerbates neuroinflammation and astrocyte-mediated cell death