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Three RCTs [3234] involving 204 patients provided moderate certainty evidence (Table 2) that L-carnitine supplementation significantly changes in the HDL cholesterol levels (MD: 1.14, 95%CI: 0.21 to 2.07) and low certainty evidence (Table 2) that L-carnitine supplementation may induce or no difference on changes in the LDL cholesterol levels (MD: 6.80, 95%CI: 23.27 to 9.68)