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GLP-1 = Glucagon-Like Peptide-1

A 2026 analysis in eClinicalMedicine , part of The Lancet family of journals, found that patients regained about 60% of the weight they lost within the first year after stopping GLP-1 therapy

WeightWatchers Clinic Weight Watchers Clinic offers GLP-1 medication and ongoing support for those who qualify

These symptoms tend to occur when dose adjustments are made too quickly, so slow titration is an important part of treatment

Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied