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FIGURE 1 Although it has been shown that bone displays an IGF-1 isoform profile different from that found in other tissues such as liver (West et al., 1996), it remains unclear how differential expression of these IGF-I isoforms plays a role in osteogenic processes

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Alveolar macrophages derived from circulating monocytes recruited into the lungs by monocyte chemotactic factors produced by lung cells are increased 20-fold in COPD patients and release ROS as superoxide anions and hydrogen peroxide (102)