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There is no standard trajectory or path for disease progression

Hesperidin (Matias et al., 2017), rutin (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)

Statistical analysis Statistical analysis was performed using parametric two-way mixed model ANOVA (one factor is repeated-measures) and Student Newman-Keuls test to compare the difference between groups

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L., Rudser, K