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Tirzepatide represents a dual agonist, targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which may explain its enhanced efficacy in clinical trials

Proc Natl Acad Sci 95:1204912054

The dose-dependent activation of the FAK-paxillin pathway was confirmed as a key mechanism

GHRH pulses primarily determine the amplitude of GH secretory bursts by maintaining somatotroph GH synthesis capacity and directly stimulating release during permissive periods when somatostatin tone is low

Its role is to help regulate blood sugar by stimulating insulin production and lessening glucagon secretion, a hormone that raises blood sugar levels