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271 Thus, indicators such as amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity and functional connectivity (FC) have shown promise as neuroimaging markers for MDD

These long-lasting, unregulated inflammatory processes can eventually lead to impaired self-tolerance of certain body structures by causing misdirected activity of the B cells of the adaptive immune system, which are responsible for the formation of characteristic autoantibodies against body structures, such as in systemic lupus erythematosus [6]

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