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Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor

Parkinsons disease-associated proteins like -syn, parkin, LRRK2, and DJ-1 have also been reported to activate microglia (Wilhelmus et al., 2012)

ROS are some of the most common oxidants in cells, containing oxygen free radicals, e.g., hydroxyl radical (HO), hydroperoxyl radical (ROO), singlet oxygen, superoxide (O2-) and hydrogen peroxide (H 2 O 2 ) (Fig

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This separation of pathways is what makes the theoretical combination interesting from a research perspective