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In fact, treatment with the bacterium Akkermansia muciniphila diminished the inducement of a depression-like behavior caused by chronic stress, where the regulation of this metabolic profile stands on such variables as acute corticosterone, dopamine, and BDNF (Ding et al., 2021)

10.1073/pnas.2002880117 62 VakhrushevaA

Its active compound, silymarin, possesses potent antioxidant and anti-inflammatory properties

The peptide downregulates TNF- (6.2-fold reduction) and IL-6 (4.1-fold reduction) while upregulating anti-inflammatory IL-10 (8.1-fold increase)[12]

A genetic screening revealed that a transporter called SLC33A1 oversees this process