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indicates that PAC, in the absence of adequate, physiological levels of GSH, may give rise to genotoxic quinone imine metabolites ( The production of quinone imine metabolite is the primary responsible for PAC liver and kidney toxicity

On the other hand, if you have no absorption issues and prefer the convenience of taking a supplement at home, oral B12 supplements could be the more practical choice

If their striatal synaptic terminals are exposed to toxins from the blood due to a leaky BBB, then this could represent a very early pathogenic event, perhaps even prior to -synuclein pathology

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doi:10.1016/j.jnutbio.2015.11.006