The lack of clear labeling and variability in individual sensitivities can make selecting supplements daunting
Both the Kidney Disease Improving Global Outcomes guidelines and American Diabetes Association Standards of Care recommend GLP1-RA as the preferred glucose lowering class for people with T2D and moderate to advanced CKD or ESRD because of their demonstrated cardiovascular benefits in people with T2D at high risk of cardiovascular disease, which includes CKD 13,14
Inhibiting the expression of iron response element binding protein 2 (IREB2), the main transcription factor of iron metabolism, can significantly increase the expression of FTL and FTH1, thereby inhibiting ferroptosis induced by erastin 28
In vivo , apigenin reduces the secretion of pro-inflammatory factors (IL-1, IL-6, and TNF-), reduces the expression of the DCs costimulatory molecules CXCR4 and MHCII, and reduces the number of Langerhans cells
Practical planning tips if pregnancy is possible Tell your prescriber if you are trying to conceive, not just after a positive test
