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BDNF is a member of the neurotrophin family, where the precursor (proBDNF) undergoes proteolytic cleavage into the mature BDNF (mBDNF) through the tissue-type plasminogen activator (tPA)-plasmin (Tsai 2007)

Gastrointestinal symptoms are commonly monitored across incretin-based therapies, but patients should rely on approved labeling for approved medications and clinical-trial oversight for investigational medications