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This is an Open Access article distributed under the terms of the CC BY license (

Parkinsons Dis., 2023 , 4709322

) Summary and Conclusions Genetic variation in folate metabolism has emerged as a critical area of investigation, not only for its role in rare hereditary disorders but for its far-reaching implications in common, multifactorial conditions such as cardiovascular disease, birth defects, cancer, and neurodevelopmental disorders