Mecobalamin plays an important role in transmethylation as a coenzyme in the synthesis of methionine from homocysteine
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The reduction in hepatic fat in HIV-associated fatty liver disease, alongside the primary visceral-fat effect, has been characterized in randomized trials, and the mechanistic follow-up identified reductions in fibro-inflammatory mediators (VEGFA, TGF-1, CSF1) that track with improvements in liver-injury scores
Leung AK, Robson WL, Liu EK, Kao CP, Fong JH, Leong AG, et al