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Therefore, LDHA inhibitors can be used as a way to delay the progression of OA and even reverse the pathological state of OA in future treatment ( 3.4 PFKFB3 and OA The involvement of 6-phosphofructo-1-kinase (PFK-1) as a regulator in catalyzing aerobic glycolysis is another important rate-limiting step
Aliment Pharmacol Ther 19:537544 Schields WW, Thompson KE, Grice GA, Harrison SA, Coyle WJ (2009) The effect of metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): a pilot trial