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Why this trial matters: First triple hormone receptor agonist showing major Phase III weight-loss efficacy Delivers weight-loss outcomes far beyond many current therapies Suggests a potential new metabolic and obesity care benchmark Semaglutide Shows Consistent Liver Benefits in MASH In the Phase III ESSENCE study, once-weekly semaglutide 2.4 mg significantly increased rates of steatohepatitis resolution and fibrosis improvement on liver biopsy in adults with metabolic dysfunction-associated steatohepatitis (MASH), compared with placebo

According to the results from the proposed policies model, large practice rural clinicians (100+) have a slightly lower median final score (87.74) than it (89.89) is for all MIPS eligible clinicians practicing in large practices

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Injectable Semaglutide : Weekly regimen administered via injection