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The ratio and 90% confidence interval of IcoSema/icodec was 1.04 [0.99;1.08] for area under the curve from zero to last quantifiable observation (AUC 0 t ) and 1.02 [0.96;1.09] for maximum concentration ( C max ), i.e., within the bioequivalence acceptance interval of 0.801.25

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It also gives the impression of intensifying the growth of beta-cells within the pancreas

Antigen-presenting cells (APCs) modulate immunological tolerance under physiological conditions, preventing aberrant immune activation while preserving immune surveillance (35)