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4 In a follow-up study, researchers found that supplementing with vitamins B12 and B9 (folic acid) may increase the risk of colon cancer

We have previously demonstrated that these fluxes of cytosolic glutamate can occur without detectable increases in oxidative stress or altered cell viability (16)

But it means its even more important to plan what happens after weight lossdietary change and physical activity remain essential. Ongoing research is exploring maintenance-phase strategies, lower dosing and alternative compounds that might preserve metabolic benefits while minimizing side effects