New England Journal of Medicine Zheng Z et al
GLP-1 receptors in the mesolimbic system are implicated in the modulation of reward behavior [134], while brain imaging studies document GLP-1-induced changes in brain regions related to appetite and reward, such as the insula, amygdala, putamen, and orbitofrontal cortex [135]
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Long-acting formulations have been engineered for extended duration of action