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AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)

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Additionally, glycosylation of -syn has been shown to increase its binding to GAPDH, leading to greater enzyme inactivation and a further reduction in glycolysis [73]

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BPC-157 upregulates vascular endothelial growth factor (VEGF), initiating angiogenesis, the formation of new blood vessels that restore oxygen and nutrient delivery to damaged tissue