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Shrinkage of experimental benign prostatic hyperplasia and reduction of prostatic cell volume by a gastrin-releasing peptide antagonist
On phase: 3 months of active dosing at 25 units per day
Together, the UPR sensors alleviate ER stress by attenuating global protein synthesis to reduce the load of unfolded proteins, increasing chaperone synthesis to guide protein degradation or refolding misfolded proteins, and synthesizing lipids to increase ER volume (29)
If a top-tier CDMO encounters a quality failure, a regulatory hold, or operational disruption, the absence of broadly distributed backup capacity means that disruption propagates directly to patients
