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Any betaine is defined as neutral zwitterionic compound possessing a positively charged cationic functional group, such as a quaternary ammonium, that has no hydrogen atoms, along with a negatively charged anionic functional group, such as a carboxylate group

Study approval The study protocol was approved by the Human Investigations Committee of the Yale School of Medicine

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Since GLP-1-induced insulin secretion requires glucose metabolism, we aimed to address the hypothesis that GLP-1 receptor (GLP-1R) signalling can modulate glucose uptake and utilization in -cells