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56 The clinical correlate of this age-related enzyme instability is that hemolysis in patients with G6PDA generally is mild and limited to older deficient erythrocytes

Goyens P, Golstein J, Nsombola B, Vis H, Dumont JE

TranDCDangALHoangTNLNguyenCTLeTMPDinhTNMet alPrevalence of thalassemia in the Vietnamese population and building a clinical decision support system for prenatal screening for thalassemia

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thats why once-weekly dosing works and why levels decline over several weeks after stopping, per the FDA prescribing information