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TDP-43 is usually found in the nucleus, but in many cases of ALS it accumulates in the cytoplasm (TDP-43 proteopathy) (Thakur et al

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As of January 2025, efgartigimod is the only FcRn antagonist with registered (albeit in not all cases ongoing) trials within bullous pemphigoid, post-coronavirus disease 2019 (COVID-19) postural orthostatic tachycardia syndrome, membranous nephropathy, and antineutrophil cytoplasmic antibody-associated vasculitis, and disclosed development plans detail an investigation of efgartigimod within more than ten indications [245]

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Comparing blood work changes: tirzepatide vs semaglutide Since many researchers switch between or compare these two medications, understanding how their blood work effects differ is valuable