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The Author(s) 2026

Cefalu, Corby K

The mean age of the study patients was found to be 32.90 7.92 years which was similar to the studies by Kumar et al .,[] Garg et al .,[] and Achar and Rathi.[] The disease duration of melasma in majority of patients (56.0%) was between 1 to 3 years, which is in concordance with the study by Kumar et al .[] Similar to the study by Khurana et al ., majority of patients (78%) in our study were found to be of Fitzpatrick skin type IV, followed by Fitzpatrick skin type V and type III.[] The assessment of mean difference in VAS over both cheeks before and after TA (right cheek) and glutathione (left cheek) revealed that both the treatment options were effective [Table 2]

For TP53-R72P overexpression experiments fully differentiated (day 7) C3H10T1/2 CrispR/Cas9 p53 KO adipocytes were detached using trypsin (0.25%)/collagenase (0.5 mg/ml), washed with PBS and resuspended in electroporation buffer R (Neon Transfection system, MKP1096, Invitrogen) to 6 10 5 cells per 10 l

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