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The dose initiation, escalation, and maintenance schedule for Wegovy subcutaneous injection is as follows: Weeks 1 to 4: 0.25 mg once weekly Weeks 5 to 8: 0.5 mg once weekly Weeks 9 to 12: 1 mg once weekly Weeks 13 to 16: 1.7 mg once weekly Week 17 onwards: 2.4 mg once weekly maintenance dosage Wegovy can produce significant weight loss over several months to a year, but the results are not instant

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Risk of bias for the change in HbA 1c was assessed as low in all trials except for one that was at high risk of bias and one with some concerns (ESM Table 2)

Dosing was later increased to 5mg, each time with additional improvement and only transient mild nausea with the initial dosing

The program operates on a cash-pay basis