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Individuals consuming diets high in UPF content have been shown to exhibit altered lipid profiles, including shifts in key lipid species involved in neuroinflammation, cell membrane integrity, and neurotransmitter signaling, all of which may contribute to depressive symptoms ( de novo lipogenesis, which led to abnormal lipids and contributed to inflammation and impaired neuronal function ( Figure 4 Figure 5 Notably, the consumption of UPF can adversely affect the permeability of important lipid membranes, including the BBB ( 3.2.3.2 UPFs and increased inflammation Refined carbohydrates, sugars, and hydrogenated fat ( The association between the consumption of UFP and depressive symptoms has been linked to changes in systemic inflammation (Figure 6)

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