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Such local side effects are usually transient and self-limited

doi: 10.4049/jimmunol.167.8.4137 128 LiTJJiangYMHuYFHuangLYuJZhaoLYet al

For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks

The dose-response curve in animal studies shows activity across a wide range, but there is a floor below which effects diminish (Krivic et al., 2006)

The combined statistics for all final reassigned complex code combinations are represented by an alphanumeric code with the first four digits of the designated primary service followed by a letter