Through experimental methods such as molecular docking, CESTA, and non-targeted metabolomics, we found that SAC can act on the Keap1/Nrf2/GPX4 signaling axis and regulate glutathione metabolism, effectively inhibiting ferroptosis and oxidative damage in colonic epithelial cells, thereby alleviating UC
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Besides that, flavonoids exhibit antimicrobial activity by establishing complexes with the bacterial cell wall, inhibiting enzyme activity, and preventing microbial growth [25]