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The skeptical cardiologist, like most physicians, has always assumed that weight loss, whether accomplished by diet/exercise, bariatric surgery, or drugs would benefit obese patients since it results in lower blood pressure, improved cholesterol, and less diabetes but until the SELECT RCT was published we lacked solid evidence that any weight reduction therapy would lower the risk of heart attack, stroke, and cardiovascular death

Yancey PG, de la Llera-Moya M, Swarnakar S, Monza P, Klein S, Connelly M, Johnson W, Williams D, Rothblat GH

Mammalian glucokinase and its gene

HOMA-IR, Homeostasis model assessment insulin resistence

Hydration and Electrolytes: GLP-1 agonists can cause dehydration due to nausea and reduced thirst