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Disordered Hemostasis in Liver Disease As was discussed earlier and in Chapter 59, the liver manufactures most of the soluble clotting factors (the major exceptions being factor VIII and von Willebrand factor), as well as a number of inhibitors of clotting (proteins C and S, antithrombin)

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Concha, J

As the TCA cycle oxidations drive the reduction of LA, the cycle stalls with a high reducing potential within the components of the TCA cycle and accumulation of dihydrolipoamide

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