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In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

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10.3390/toxins11110635 76 Posada-AyalaM.ZubiriI.Martin-LorenzoM.Sanz-MarotoA.MoleroD.Gonzalez-CaleroL.et al (2014)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Duta-Bratu C.-G., Nitulescu G.M., Mihai D.P., Olaru O.T