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In a study of 2,539 patients assigned to take either tirzepatide or placebo for 72 weeks, the average weight loss achieved for patients taking tirzepatide 5 mg was 15%

Expression of Concern, not retracted

doi:10.1186/1471-2377-11-139 Tirouvanziam R, Obukhanych TV, Laval J, Aronov PA, Libove R, Banerjee AG, Parker KJ, O'Hara R, Herzenberg LA, Herzenberg LA, Hardan AY: Distinct plasma profile of polar neutral amino acids, leucine and glutamate in children with autism spectrum disorders

Holman RR, Bethel MA, Mentz RJ, EXSCEL Study Group, et al

Rapid weight loss typically results in significant lean mass reduction, sometimes approaching 25-40% of total weight lost