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Histone deacetylases (HDAC), common in mammals [33, 50], are de-lactylation enzymes that effectively remove Kl-la and Kd-la modifications

Acknowledgements We thank the staff of the Analysis and Testing Center of Yangzhou University for their technical assistance

Retatrutide can reduce thirst perception while GI side effects cause fluid loss

Bayik, D

Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]