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Cell Death Differ (2009) 16:153950

487,488 Increased ECM rigidity worsens the functions of senescent cells by boosting the secretion of matrix metalloproteases, intensifying ECM damage, and triggering pathways that promote senescence, fibrosis, and inflammation

To be mixed with a specialised activator before use, this extraordinary concentration targets visible textural damage, uneven tone, enlarged pores and radiance to promote an overall healthier-looking complexion

The levels of SODs decline with age, whereas free radical formation increases