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The American Journal of Clinical Nutrition, 120 (4), 854863

Each receptor it activates produces a distinct effect: GLP-1 receptor: suppresses appetite and slows digestion, reducing overall caloric intake GIP receptor: increases insulin sensitivity, supporting better glycemic control Glucagon receptor: boosts fat metabolism, driving energy expenditure independent of diet These three pathways point toward two outcomes: meaningful weight loss and improved glycemic control

GIP receptor activation enhances insulin secretion, improves fat metabolism, and may contribute to central nervous system effects on appetite that go beyond what GLP-1 alone can achieve